Wellbutrin And Sex Drive: Does Wellbutrin Affect One’s Sexual Health?

Regarding breast-feeding, caution is advised since bupropion does pass into breast milk. This risk increases if you have heart disease, high blood pressure, previous heart attack, or irregular heartbeat, or when used with transdermal nicotine replacement products. Participants in the experiment group were taken bupropion tablets 150mg daily and placebo tablets with the same size and color that were indistinguishable with the matching bupropions were given to the control group for one-month period of observation. The dose usually ranges from 100 mg twice daily up to 200 mg twice daily. Side effects with bupropion are generally mild and often resolve over the first 1-2 weeks of treatment as you continue to take the medication. These medications can change the way your body reacts to bupropion. So, does Wellbutrin hypersexuality side effect exist? Crenshaw knew that the SSRIs and most other antidepressants cause sex problems.

(965 mm OD) inserted into the urethra, via a bladder incision, that was firmly tied to the bladder neck. Taking a drug holiday involves taking your usual Thursday morning dose and then nothing again until noon on Sunday, when you resume your previous schedule. This numbers were accessible only to authorized individuals who were not involved in the conduct or analysis of the study, until the time of un-blinding. But the damage had been done.

Female receptivity was induced by sequential subcutaneous injection of estradiol benzoate (4 μg per rat) followed 44 h later by progesterone (2 mg per rat).

These medications work by blocking the reuptake of the brain chemical serotonin, which helps regulate mood. Clomipramine appears to have the highest rates of sexual dysfunction—particularly anorgasmia—probably because it inhibits the serotonin transporter more than do other TCAs. This study considered the possibility of seizures and psychosis is likely to bupropion. This drug has a good impact on cognition and improves sexual function. J Clin Psychiatry 2020, 66: It is a safe and effective medication when used as directed.

While shopping, she said, she spontaneously had an orgasm that had lasted on and off for nearly two hours. Regulatory agencies from several countries are warning that antidepressants may induce birth defects including heart and lung malfunction, preterm births and numerous other physical defects. This case report suggests that physicians should be aware that bupropion may induce unusual sexual side effects such as spontaneous orgasms. Food and Drug Administration (FDA). They do a great job of parting the black clouds of depression, and many people swear that SSRIs have improved their lives dramatically. Beta-blockers lower blood pressure by blocking the effects of the hormone epinephrine, also known as adrenaline. Its nonsexual side effects are no worse, and it’s unlikely to cause sexual side effects. 3'-Chloro-propiophenone 3'-Chloro-2-bromopropiophenone Bupropion hydrochloride This diagram shows the synthesis of bupropion via 3'-chloro-propiophenone.

25 The subjects had previously been stabilized on citalopram, fluoxetine, paroxetine, or sertraline for a minimum of 3 months.

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9 - 11 This may lead to side effects of sexual dysfunction, as testosterone may affect sexual arousal and dopamine plays a role in achieving orgasm. There are no currently approved pharmacological treatments for women with orgasmic disorder. Penis rings, feeling of trapped semen. Fortunately, one antidepressant rarely causes sexual side effects, Wellbutrin (bupropion). After starting bupropion, symptoms gradually decrease over a period of weeks. The catheter was connected to a Harvard syringe pump (Model 2020; Harvard Instruments) to mechanically stimulate the urethra.

  • Everything changed—no more dryness, no more pain.
  • Some of them come back quite happy with this unintended side effect.
  • Also all participants were to remain blinded to study until ending of the double-blind clinical data.
  • Fortunately, after a few months, tremors usually subside.
  • The mean (SD) for Female Sexual Function Index total score was higher in the bupropion sustained release group (25.)


The study has shown that using the bupropion can be used in purpose of treatment of orgasm disorder. Specifically, bupropion, mirtazapine, and serotonin-norepinephrine reuptake inhibitors (SNRIs) are antidepressants generally viewed as having less risk for sexual side effects. Thereafter, urethral stimulation (US) was applied to induce GMPE expression. Bupropion is known to weakly inhibit the α 1 adrenergic receptor, with a 14% potency of its dopamine uptake inhibition, and the H 1 receptor, with a 9% potency. Imipramine has an alpha-adrenergic effect and appears to be effective in psychotropic-induced male orgasmic disorder (MOD). Three days later she appeared in the consultation room, presented a sense of pre-orgasmic of 72 hours of evolution, high increased libido, tiredness, muscle tension and insomnia. In addition to its similar effectiveness in the treatment of depression, it separates itself from many of the other available antidepressants by its activation, decrease in anhedonia via improvement of the impaired reward processing seen in depression [3], and superior sexual side effect profile which includes alleviation of sexual side effects induced by selective serotonin reuptake inhibitors (SSRIs) [4].

Bupropion XL is usually taken once daily in the morning. The tablet shell from the SR and XL forms may appear in your feces. It is also known to cause down-regulation of beta-adrenergic receptors, desensitization of adenyl cyclase, and down-regulation of serotonin receptors. Susan fell into that unlucky percentage, and she asked me if anything could be done. In 1987, when Crenshaw's study was published, the Graedons publicized Wellbutrin's apparent pro-sexual (i. Coronavirus spreads quickly and sometimes before people have symptoms, study finds. )

Antidepressants have been commonly associated with sexual side effects in the libido, sexual arousal, orgasm and erectile function.

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Overall, bupropion reversed sexual dysfunction caused by SSRIs in 66% of the subjects when used consistently. Little did I know. If an overdose occurs, whether intentional or accidental, immediate medical attention may be necessary. Both believed fluoxetine remained of partial benefit and bupropion was started at 150 mg daily as an adjunctive intervention to assist mood and anxiety.

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and The ObG Project. A randomized, placebo-controlled, crossover study of ephedrine for SSRI-induced female sexual dysfunction. It's almost off patent. ” Understanding the benefits and risks of each strategy can help you: There are many psychological and physical ailments that can affect your sexuality other than depression and medications. If a patient finds that the medication produces more pronounced side effects at particular times of the day, it may be possible to schedule sexual activity for the time when side effects are least bothersome — or to take the drug at a different time. The researchers asked the participants to have sex at least twice a week for the duration of the study, and to keep detailed diaries of their erotic experiences.

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It rather enables good sexual health. Related articles, the surgeon or health care expert in the surgeon's office will talk about how to inflate and deflate the implant. However, the relatively small numbers assessed for many of the interventions studied means that the possibility of such an effect cannot confidently be excluded in all cases. It's been pretty dreary here, but I think the GF has a hard time believing that the weather could impact me like so. 15 Like paroxetine, citalopram also appears to have a high frequency of sexual dysfunction, but this finding was not replicated in other studies. EBSCO EBSCO DynaMed website.

[68] As of 2020 there were two case reports of people experiencing withdrawal symptoms when discontinuing bupropion taken to aid smoking cessation;[69] the prescribing information states that dose tapering is not required when discontinuing treatment for smoking cessation.

Twenty-two of these trials investigated the addition of medication to treat the identified dysfunction, with most agents studied in only single studies. 5-fold increase in the 18–24 age group. Hall-Flavin, M. It is one of the most frequently prescribed antidepressants in the English-speaking world. The inclusion criteria of participants were: Men receiving tadalafil were more likely to report improved erectile function ( RR 11. )

However, "in the studies I saw where it has a positive effect on sex drive, the effects did seem to decrease over time. "Studies have reported this in 58% to 73% of men [9]. Saiz-Ruiz et al. Bupropion IR is usually taken 2 or 3 times per day with 4-6 hours between doses. This is the case of a 57-year-old Caucasian male with a reported past history of major depressive disorder, adjustment disorder, anxiety disorder, and pedophilic disorder, referred by his primary care provider for “sad mood and irritability. 21 The parameters used to describe the acute and chronic effects of BP on the expressed GMPEs were the number of discharges and the frequency of discharge, and the number of successive GMPEs that could be evoked before response inhibition was also registered. This involves maintaining your current level of paroxetine, while adding a second medication to offset the sexual side effects.

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The dopaminergic system may play another role in spontaneous orgasms. HuffPost is part of Verizon Media. Amantadine has been used, but studies have not proven that it is beneficial.

There were some limitations in this study that may cause the results of this study non-generalizable. To date, there are no known problems associated with long term use of bupropion. When the subjects were specifically asked about sexual side effects, the rates rose to 40 percent to 50 percent. There were no other consistent differences between classes of antidepressants. Today, a dozen years after its release, with no evidence of unusually high seizure risk, "Drug Facts and Comparisons" still includes a warning about its seizure risk.

But the studies also left him frustrated.

For some people, sexual side effects are minor or may ease up as their bodies adjust to the medication.

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001), orgasm (4. There are several products with the active ingredient bupropion. Everything is just peachy there, aside from my "problem. "A man may need to balance out the amount of painkiller with testosterone to reduce pain but still maintain his sex life. If a man still wants to use Trazodone for helping with sleep, he needs to follow Trazodone’s dosage instructions to reduce the possibility of priapism. Within one week of taking bupropion XL, the patient began repeatedly to experience spontaneous unwelcome orgasms 3-4 times a night at sleep, which had never happened in the past. Sexual function was assessed by using the sexual function domains of the Female Sexual Function Index (primary efficacy outcome measure) and the Clinical Global Impression Scale adapted for sexual function (secondary efficacy outcome measure).

Sexual side effects appear to be more prevalent with MAOIs than with TCAs,4 perhaps similar to the rate seen with SSRIs. The more activity you have, the more pliable the vaginal tissue remains. Vyvanse vs. strattera, men who smoke are about twice as likely to develop ED as nonsmokers. These medications are approved by the Food and Drug Administration only to treat sexual problems in men. Because most patients are reluctant to bring up any sexual side effects on their own, the researchers got the false impression that these drugs had little effect on sexuality. A small double-blind study by Clayton et al. The patient was scared and wanted to stop taking bupropion, but he first sought the counsel of his healthcare provider. But in addition to typical antidepressant side effects -- nausea, nervousness, insomnia, diarrhea, dry mouth and tremor (hand shaking) -- the SSRIs have become notorious for causing sex problems:

Studies show that like the SSRIs, Wellbutrin's other side effects are pretty mild and usually temporary. A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressantinduced sexual dysfunction. This expected side effect lasted for one week.


For some people experiencing sexual side effects when taking SSRIs, switching to an NDRI like Wellbutrin is enough to solve the problem. Sexual health basics, they are sildenafil (Viagra®), tadalafil (Cialis®), vardenafil (Levitra®) and avanafil (Spedra®). Besides, the psychiatric health care system in Iran is based on Government, ensuring a representative sample of patients with Schizophrenia. It enhances activity in central dopaminergic and noradrenergic neurotransmitter systems, which are associated with the regulation of the sexual response in humans (20). 20,21 A double-blinded randomized study sought to assess whether once-daily bupropion (XL) or extended-release venlafaxine (XR), an SNRI, was more appropriate for decreasing the risk of sexual side effects. Your mental health provider should justify his or her thinking in recommending an “off-label” treatment. This because the SSRIs or selective serotonin reuptake inhibitors used in antidepressants influence the neurotransmitters in the brain, causing a delay in ejaculation. The efficacy of herbal supplements to treat the sexual side effects of SSRIs is not clear.

  • There have been fewer studies of pharmacological treatment for hypoactive sexual desire disorder in premenopausal women.
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  • No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
  • The study results were reported in the medical trade press, and you could almost hear the prescription pads snapping shut from coast to coast.
  • The primary objective of this study is to evaluate the effect of bupropion XL on the ease and frequency of achieving orgasm in sexual activity.
  • The last point is that different doses of the drug to achieve minimum effective dose with minimal side effects has not been investigated that is important because of the effect of bupropion on dopamine pathways.


Communication will be very important—not just with your partner, but with your health care team. There is also less chance of weight gain, sleepiness, and sexual dysfunction than with other forms of treatment. Hypoactive sexual desire disorder (HSDD) is a common, but not frequently discussed, sexual health condition. This lets you have an active sex life, and that keeps things working. The dose ranges from 150 mg to 450 mg. J Psychopharmacol 2020, 20: On the heels of those came mood swings and depression, followed by dryness and pain during sex, which naturally made me want to do it less often. Bupropion is less likely than other antidepressants to cause sexual dysfunction.

Stark problems created when pregnant women take antidepressants are internationally recognized. The most commonly reported side effects of bupropion are headache, weight loss, dry mouth, trouble sleeping, nausea, dizziness, constipation, fast heartbeat, and sore throat. Once you confirm your privacy choices here, you can make changes at any time by visiting your Privacy Dashboard. Paper presented at 41st Annual New Clinical Drug Evaluation Unit (NCDEU) Meeting.

Medical researchers are still not completely sure how and why it works.

Another limitation of this study was time limits on the duration of the study so that it made us unable to trace bupropion effects on patients in medium-term and long-term. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. There are three types of bupropion; the immediate-release form of bupropion has been available in the United States since 1989, a SR formulation followed in 1996, and in August 2020, the XL formulation was introduced. 1–3 Symptom onset occurs at the adolescence and its prevalence is about 1 percent of the general population and its diagnosis is based on patient-reported experiences and observed behaviors. There has been controversy about whether it is useful to add an antidepressant such as bupropion to a mood stabilizer in people with bipolar depression, but recent reviews have concluded that bupropion in this situation does no significant harm and may sometimes give significant benefit. She had been using 100mg/day quetiapine for approximately 10 years and 25mg/day agomelatine for one year. Bupropion lowers the threshold for epileptic seizures,[74] and therefore can potentially interact with other medications that also lower it, such as carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, theophylline, systemic corticosteroids (e. )(5 and 15 mg kg−1) have antidepressant-like effects in animal models and a modest impact on locomotor behavior.

The sustained-release preparation is associated with a seizure incidence of 0.

  • Unlike many antidepressants, bupropion does not commonly cause sexual side effects and may be selected as an alternative treatment when antidepressant-induced sexual side effects are problematic.
  • I'm male, and in my late 20's, so I find it hard to believe this could be an age related thing - and the idea of having to take another pill is not one I relish.
  • A common solution to alleviating sexual problems caused by antidepressants is to start taking an additional drug that specifically targets sexual dysfunction.
  • Diuretics cause the kidneys to remove more sodium and water from the body, relaxing the blood vessel walls.
  • Sexual dysfunction can also be caused by certain behaviors.

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When switching from MAOIs to bupropion, it is important to include a washout period of about two weeks between the medications. If you’ve tried making adjustments to your antidepressant or switching meds but the sexual side effects persist, you may want to shift your focus to other approaches. Grimes and Labbate (21) reported a case of spontaneous orgasm with the combined use of bupropion and sertraline. There was no history of alcohol abuse or recreational drug use in our patient. Have you had similar experiences with any of these drugs?

It does not usually lead to weight gain or sexual dysfunction.

With input from you, your health care provider will assess how long you will need to take the medicine. Click to expand. SSRIs can also lower a man’s testosterone levels, making climax even more unlikely. Anorgasmia is the most commonly reported sexual symptom. The common antidepressant medications—Prozac, Paxil, Zoloft and Lexapro—do more than just remove depressive thoughts.

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Bupropion may also be helpful when prescribed “off-label” for bipolar disorder, attention deficit hyperactivity disorder (ADHD, and sexual dysfunction due to SSRI antidepressants. )A study has shown that using antidepressant drug could worsen the sexual dysfunction and by changing the drug with bupropion the orgasm will be improved. And not only haven't I encountered the weight gain that people often complain of with selective serotonin reuptake inhibitors (SSRIs) like Prozac but I feel as if my metabolism got a boost. Epileptic seizures are the most important adverse effect of bupropion. 9% for citalopram. No one interviewed for this article called Wellbutrin an aphrodisiac. My guess is that women are going to be more reluctant to discuss this stuff with you.

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Share on Pinterest Bupropion, or Wellbutrin, is a commonly used antidepressant. 5% at recommended dosage levels. 4% for dosages below 450 mg; the incidence climbs to 5% for dosages between 450–600 mg per day. Brain dopamine systems between the hypothalamus and limbic system are thought to be the main sexual excitatory systems (7,15). In the UK, more than 7,600 reports of suspected adverse reactions were collected in the first two years after bupropion's approval by the Medicines and Healthcare Products Regulatory Agency as part of the Yellow Card Scheme, which monitored side effects. All other medications you are currently taking and any medication allergies you have.

It is believed its atypical mechanism of actions provides further benefit over SSRIs in its ability to improve anhedonia [3], fatigue, motivation, and focus [8], all were difficulties reported by our patient. Click 'Learn More' to learn and customise how Verizon Media and our partners collect and use data. While depressed mood and lack of interest in activities may need up to 4-6 weeks to improve, disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks. One of its more troublesome adverse effects is sedation. 5% reacted poorly and seriously considered whether to continue the antidepressant treatment. Considered in isolation, bupropion was not statistically different from placebo. Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid (Marplan), phenelzine (Nardil) and tranylcypromine (Parnate).

Most antidepressants are known for lowering patients libido and sexual desire. Efficacy and safety of sildenafil in men with serotonergic antidepressantassociated erectile dysfunction: Deciding when to take your medication will depend on many factors, such as your daily routine or other side effects you experience (such as nausea, which may be reduced if you take your pill with food, or trouble sleeping).


Wait and take your next dose at your regular time the next day. In the past few years, several studies published in respected journals -- but ignored by the mass media -- have confirmed Crenshaw's findings and extended them. When bupropion is advocated to combat depression, the fear of the sexual side effects of Wellbutrin commonly comes up. In addition to overall improvement in their sexual functioning, one woman reported the first orgasm of her life, and another woman experienced her first multiple orgasms. Wellbutrin was a seizure-tainted drug.