Hello statins, goodbye erectile dysfunction and bad cholestrol? Study says yes!

National regulatory adverse drug reaction registers were also examined. All statins were implicated. Have a question? ED problems due to organic causes comprise up to 80% of cases, while vascular disease is the most common pathophysiology of ED [12]. Although 37% of subjects improved, none of the patients regained completely normal erectile function as defined by an IIEF-5 score greater than 21. This was a substudy of the Heart Outcomes Prevention Evaluation -- 3 (HOPE-3) randomized controlled trial, a 2x2 factorial randomized controlled trial testing candesartan/HCTZ versus placebo, rosuvastatin versus placebo, and the combination of these medications versus double placebo. Common causes of the condition include high cholesterol level, high blood pressure, tobacco use, stress and diabetes. Men who suffer from erectile dysfunction (ED) may find that taking statin does not just help them reduce the amount of bad cholesterol in their body as the cholesterol lowering drug can also apparently help improve their erectile function. The effect of fluvastatin on penile blood-flow and erectile function in patients with arteriogenic erectile dysfunction and cardiovascular risk factors will be determined in a cross-over design. Additionally, in an experimental model of diabetes characterized by RhoA/ROCK overactivity, ED, and hypogonadism, it has been demonstrated that both testosterone and statin therapy restored electrically stimulated penile erection by down‐regulation of the RhoA/ROCK pathway; moreover, the effect of statin was obtained independently from the concomitant hypogonadal state ( Morelli et al, 2020 ).

  • Overall, erectile function scores increased by 3.
  • In the first meta-analysis of previous studies on erectile dysfunction and statins, researchers identified 11 randomized, controlled trials that measured erectile function using the International Inventory of Erectile Function – a self-administered survey with five questions, each scored on a five-point scale and totaled, with lower values representing poorer sexual function.
  • Almost all of these patients were taking statins (92%)—47% assumed β‐blockers and 28% diuretics (Kloner et al, 2020).

The mean age of the 60 impotent patients was significantly higher than in the other subjects, and these patients had higher levels of blood glucose. In the study by Wingard and colleagues ( 2020 ) erectile function was evaluated by assessing voltage‐dependent stimulation of the cavernosal nerve in 16‐20‐week‐old lean and obese diabetic Zucker rats treated with 5 mg/kg daily of rosuvastatin intraperitoneally for 3 days. Physiology of erection is mainly dependent on endothelial NO-production with consecutive activation of guanylate-cyclase. Feeling feverish? it might be stress, this content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. ” To order a copy, send a check for $16 to Graedons’ People’s Pharmacy, Dept. Statins don’t touch any of these. Erectile function was subjectively assessed with the IIEF‐5 questionnaire and response to the global efficacy question (GEQ). The benefits of statins prevailed over the side effects in 10 of 11 studies reviewed, he said.

In the study presented at the American College of Cardiology conference, experts performed a meta-analysis on 11 previous randomised, controlled studies on erectile dysfunction and statins. Statins are commonly prescribed for people with ailments such as diabetes or heart disease, which can cause erectile dysfunction. Another important message was obtained from the French Pharmacovigilance System Database, with which the case/noncase method was used to measure the disproportionality of combinations between statins and ED. 0 years (1–21 years). Dr. victor marchione - jan 27,2020, at first, Kayla just thought it was her and that he needed some kind of a change to what they usually did, but later Brandon admitted that as of late, he just couldn’t seem to maintain an erection, and that it took way too much effort to go long. 4), and rosuvastatin (aROR = 7. This is suggested by three randomized clinical trials using atorvastatin (from 40 to 80 mg daily), that showed a significant improvement in ED compared with the placebo19, 21, 26 after less than 6 months using the medication. For this reason, it is unlikely that doctors will start to prescribe statins for treating ED any time soon.

Before statin administration, the median IIEF‐5 score was 21 (range, 0–25), and 57% had erectile function impairment.

Where Did The Story Come From?

On the plus side, some men report improved erections when their high cholesterol was treated with statins, said Dr. The opinions expressed are those of the author. Erectile dysfunction affects an estimated 18 million to 30 million men and occurs more often in men over the age of 40. The men were assessed by the international index of erectile dysfunction questionnaire, which asks about hardness of erections, penetration and confidence. Additionally, preincubation of aortic rings with nitro‐l‐arginine methyl ester reversed the atorvastatin‐induced increase in the potency of sildenafil relaxation. Patient guide, *The names in brackets are just some examples of the trade names each specific medicine is marketed under in Australia. The effects of statins on libido and sexual performance have been controversial for years.

  • 1%, meaning that the incidence of ED was almost three times greater for statin users.
  • The paper reports on a small but well-conducted analysis of existing data into statin use and symptoms of erectile dysfunction (inability to obtain or maintain an erection).
  • However, one study showed a statistically significant difference in erectile function in participants taking a statin vs.

Ethics Declarations

6 in the patients who did not receive atorvastatin P=0. Alfred the best, no significant difference in the effect size of testosterone therapy among those with and without coronary artery disease (test for interaction, ) was reported [36]. Similarly, Viagra was not originally intended to help men in the bedroom. We are only now beginning to realize the wide-ranging importance of cholesterol in human physiology.


In the first subgroup patients received a statin (atorvastatin) while the second subgroup received no treatment (control group). In another study, Fibbi and colleagues ( 2020 ) evaluated the effects of atorvastatin (5 and 30 mg/kg), given for 2 weeks to spontaneously hypertensive rats (SHR), on an experimental model characterized by impaired erectile function and overactivity of the procontractile RhoA/Rho‐associated, coiled coil‐containing protein kinase (RhoA/ROCK) pathway compared with their normotensive counterpart, Wistar‐Kyoto rats. The three major forms of male sexual dysfunction are erectile dysfunction (ED), ejaculatory dysfunction, and decreased libido. Examination of the 186 retrieved citations resulted in the selection of 11 randomized trials for inclusion in the meta‐analysis. That just leaves the little problem of what to tell men when statins are needed.

I plan to STOP taking this drug and maintain the lower levels by eating better.

9, 10, 11, 12 In other publications, the relationship between the use of statins and the development of ED has been considered an undefined topic. I never had blood sugar levels that high before taking metoprolol. 1%) had ED, whereas 431 (0. The situation is further complicated by the likelihood that one of the rarer side effects of statins is ED ( Schachter, 2020 ). “The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra,” said John B. Beta blockers can raise blood sugar (Drug Intelligence & Clinical Pharmacy, April 1985). 8, whereas no significant change was observed in men receiving placebo.

Medical problems that lead to a statin prescription might also be to blame for changes in sexual function, said Dr.

Further Reading

Statins and male sexual health: The lowest prices of the international questionnaire indicate significant erectile dysfunction. A meta-analysis is a mathematical synthesis of the results of the included studies. Patients were asked to have sexual intercourse at least once per week, and they received medication for 12 weeks. More recent experimental data concerning simvastatin reveals that the enhanced RhoA/Rho‐kinase pathway plays an anti‐erectile role and is associated with reduced response to type PDE5i inhibitor in diabetic animals. The drugs may help erectile function by coaxing blood vessels into dilating properly and improving blood flow to the penis. However, it was unclear whether reducing cholesterol levels would reduce ED risk or if lowering cholesterol levels could help men who already had ED. Eat healthy and regularly.

Statins, with or without sildenafil, could help men with erectile dysfunction (ED), according to Chinese researchers who conducted a literature review. 9% of cases, recovery occurred after withdrawal of statin, and rechallenge was positive in 5 cases. Life cycle of a penis, a ring is placed around the base of the penis, trapping blood and keeping it hard for longer. In clinical practice, men may be different. Box 52027, Durham, NC 27717-2027. The etiology of this condition is multifactorial but it is usually attributed to vascular lesions caused by endothelial dysfunction.

8 years and received statins for about 3. My cholesterol was elevated to 290, so my doctor prescribed atorvastatin. In them, men answered survey questions that scored their sexual ability on a five-point scale. Multivariate analysis showed that ED was dependent on the treatment with statins (odds ratio, 1. )In particular Herrmann and colleagues ( 2020 ) reported that treatment with atorvastatin improved sexual function and the response to oral sildenafil in men who did not initially respond to the administration of this PDE5i. Additionally, a trend toward improvement in IIEF‐5 with atorvastatin was significant. The researchers extracted five-item International Inventory of Erectile Function (IIEF) scores.

Statins and Testosterone: Industry Input

Men were 18-70 years of age and had an inadequate response to sildenafil 100 mg, LDL cholesterol less than 160 mg/dL, and ED for more than 6 months. Finally, there was no statistically significant difference in penile erection after intake of simvastatin or placebo (Mastalir et al, 2020). In other research, Dr. Results of this study showed that in the placebo group, impotence resolved in 2 men only after the study drug was stopped, whereas in the simvastatin group, impotence resolved in 14 men despite continued simvastatin treatment. Where did the story come from? I think [this] meta-analysis strongly shows that statin therapy improves erectile dysfunction after only a short duration of therapy. Instead, see your doctor and voice your concerns.

  • In penile tissue from diabetic animals, atorvastatin completely restored the diabetes‐induced hypersensitivity to Y‐27632 and prevented RhoA membrane translocation/activation.
  • Major risk factors for erectile dysfunction include diabetes, smoking, drug and alcohol abuse, overweight, depression, stress, heart disease and certain medical treatments.
  • Scientists were surprised how successful the cholesterol-busting drugs were in helping to combat erectile dysfunction.
  • 01) and GEQ (P =.
  • All had a temporal sequence.
  • Results showed a total of 60 cases of erectile dysfunction.
  • The research included 100 men between the ages of 40 and 70 with erectile dysfunction and abnormal cholesterol.

What's Next

Out of the 123 eligible patients with liver transplantation, 98 (79. )It seemed to do very little for the heart condition but trial volunteers reported they were getting a lot of erections. Site information & policies, what about allergy meds? In the Spanish database a series of 38 cases of ED associated with the use of statins was detected (from 1989 to 2020).

3% improvement in erection scores (from 14 to 17. )It seems unlikely that simvastatin determines ED. Updated 08 march 2020, what causes ED? (4 prior treatment, P < 0,05) compared to the control group reflecting an important improvement in erectile dysfunction (Table 1). Your doctor should be able to prescribe a medicine that won’t increase your risk for diabetes.

  • During this time, average LDL-C levels dropped significantly from 138 to 91 mg/dL in the treated men but were virtually unchanged in control groups.
  • In this evaluation, serum biochemical and lipid profile (total cholesterol, triglycerides, LDL and HDL cholesterol) analyses were performed at baseline and repeated at posttreatment weeks 6 and 12.
  • A tablet that can take on cholesterol and improve erections may sound attractive.
  • It can be a sign of future heart problems.
  • A systematic review by Rizvi and colleagues ( 2020 ) showed that a substantial number of cases of ED associated withstatinusagehavebeenreportedtoregulatoryagencies.
  • 3), simvastatin (aROR = 2.

What Kind Of Research Was This?

Past research has shown a connection between high cholesterol and an increased risk for ED. (MAP) ratio after electrostimulation of the cavernous nerve was measured. Another study evaluated the effects of adjunctive treatment with atorvastatin or the antihypertensive quinapril (an angiotensin converter enzyme inhibitor) in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Based on these studies, the use of statins for treatment for ED cannot be justified. Medicine & health, a sample of 203 subjects aged between 45 and 74 years old was assessed through the administration of International Index of Erectile Function 5 (IIEF-5) and Geriatric Depression Scale (GDS), in order to define the presence of a relationship between depressive symptoms and ED severity. The same study also pointed to the possibility that statins can aggravate existing ED. The study is published in the Canadian Journal of Cardiology. We are engaged on the issue and committed to looking at options that support our full range of digital offerings to the EU market. No source of funding was reported, but the researchers state that they have no conflicts of interest.

Lead study investigator John B. Also, a systematic review revealed that statins may cause ED []. Moreover, in human fetal smooth muscle cells derived from the corpus cavernosum (hfPSMC), atorvastatin inhibited RhoA membrane translocation and ROCK activity, as well as RhoA‐dependent biologic functions like cell migration and cell proliferation. Saltzman and colleagues ( 2020 ) in their study gave atorvastatin to 18 men with increased cholesterol as the only risk factor for organic ED diagnosed by abnormal nocturnal penile tumescence and rigidity testing. The JUPITER study showed the safety and efficacy of the use of statins in primary prevention, selecting patients according to the usCRP levels.


Statins can not only lower cholesterol, but can improve erections, according to research presented at the European Society of Cardiology Congress in Rome last week. None of the patients taking atorvastatin achieved a response of 5 to the IIEF‐5 questions, and none of the patients regained normal erectile function as defined by an IIEF‐5 score greater than 21 ( Dadkhah et al, 2020 ). Be sure to verify your new user account in the next 24 hours, by checking your email and clicking the "verify" link.

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Cholesterol lowering drugs ‘reduce erectile dysfunction’,” reports the Daily Mail. Since statins are the most commonly prescribed drug in the UK, will erectile dysfunction (whatever doctors call the condition, it still sounds pejorative) be consigned to history? As judged by a preset definition, the prevalence of potent patients 6 months after prostatectomy was 26. Jock itch, how firm are your erections (use a scale of 1 to 10)? Functionally, their use results in reduction of hepatic synthesis of cholesterol, with a compensatory increase on the membrane of hepatocytes in the number of receptors with a high affinity for low‐density lipoprotein (LDL). The association between ED and dyslipidemia have been demonstrated by several studies ( Saltzman et al, 2020 ; Miner and Billups, 2020 ), and other studies have demonstrated that statins can lead to an improvement of erectile function ( Gokkaya et al, 2020 ). (0001) with statins compared to control. The study was presented here today at the American College of Cardiology (ACC) 2020 Scientific Sessions and simultaneously published online in the Journal of Sexual Medicine[1].

Doctors commonly use this class of drugs, which includes sildenafil (Viagra), for treating ED. Other experimental data concerning rosuvastatin, in particular, was investigated by Nangle and colleagues ( 2020 ), who examined the effects of treatment with rosuvastatin on corpus cavernosum and aorta from streptozotocin‐induced diabetic mice in a 4‐week prevention study and a 2‐week intervention study after 4 weeks of untreated diabetes. Stop smoking (if you’re a smoker). It was meant as a treatment for angina. How did the researchers interpret the results? Heart disease often occurs when there is a build-up of plaque in the arteries, which decreases blood flow to the heart, brain and rest of the body. Treatment: watchful waiting for an enlarged prostate, “Sexual health should not be viewed as a luxury, but rather as an essential component to wellness,” said urologist Ryan P. The accumulation of this substance is called atherosclerosis, and it can cause some severe complications, including an increased risk of ED.