Alprostadil Injection and Suppository for Erectile Dysfunction

The injection method for these products is the same. The treatment of erectile dysfunction (ED) following radical pelvic surgery has become an increasingly important issue. Erectile dysfunction is usually a symptom of an underlying and serious disease. Carefully follow the instructions for administration which are described below. This direct application produces consistent results and has been found to be effective for 94% of injection users. The dose used in the penis is only 0. You will also need to buy alcohol pads from your local pharmacy. You should enter at a 90-degree angle until you get a blood flush in the syringe.

  • Your doctor has prescribed edex® (alprostadil for injection) , a penile injection, to treat your erectile dysfunction.
  • Other possible side effects include occasional pain, a burning sensation, or a small nodule in the shaft of the penis which disappears if you change the injection site (it is best to change sides regularly).
  • The second phase of this study involved a diary of erectile activity in which 10 of 12 patients reported improved erectile activity while receiving sildenafil.
  • ICI therapy does have certain limitations though.
  • This includes prescription, over-the-counter, vitamin, and herbal products.
  • It is very unlikely that injection in the wrong place or into the urethra will cause a problem.
  • How is Penile Injection Therapy done?

This drug makes the blood vessels expand. You should not use alprostadil injections if you have Peyronie’s disease (see our factsheet ‘ Peyronie’s disease ’), or if you have sickle cell anaemia, leukaemia, or multiple myeloma, as these may cause a prolonged erection. This holds the blood in the penis (and keeps it hard) for up to 30 minutes. Are there any brochures or other printed material that I can take home with me? When MUSE® works, it takes between 5-10 minutes for an erection to occur and it should last for between 30-60 minutes. If an erection is painful or persists for more than 3 hours the following treatment should be commenced. When the pump is engaged, pressure in the cylinders inflate the penis and makes it stiff.

What storage conditions are needed for alprostadil?

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8 Currently available pharmacotherapeutic agents are compared in Table 3. Immediately afterwards, press firmly on the injection site with either an alcohol pad or gauze with your thumb and first finger to compress the area for at least five minutes or up to 10 minutes for patients taking blood thinning medication, such as coumadin. Mix edex® (alprostadil for injection) just prior to injection. 445-452 Despite the effectiveness of this approach in producing rigid erections, many patients do not relish injecting a needle into their penis; therefore, it is not surprising that long-term dropout rates are high. Withdraw needle from penis.

  • Patients on anticoagulant drugs (Warfarin, Aspirin etc) and those with blood clotting disorders should remind the Doctor of this before commencing therapy.
  • Communicate openly and honestly about your condition.
  • These medications enhance the effect of nitric oxide secreted from the cavernous nerves, however these nerves are usually transiently injured intraoperatively diminishing the amount of nitric oxide available.
  • Whereas self-injection therapy was once a first line treatment for erectile dysfunction, it is now a safe and effective treatment should oral therapy fail.
  • For men who do not get a satisfactory result (and it is imperative to take the drugs correctly — for example, Viagra should be taken on an empty stomach one or two hours before planned sexual activity), then it is time to consider second-line treatments, such as vacuum pumps and medicines that men self-inject directly into the penis.


Push the needle in, gently but firmly, all the way to the brown hub. Use this medication exactly as it was prescribed for you. These silicone rods give the man's penis the firmness needed for sexual penetration. Our nurses do a great job of explaining the benefits and potential risks of penile injection therapy so our patients are well educated. Loosen the protective cap and place the filled syringe within easy reach prior to injection. Tell your doctor about all medications you use.

Use of ICI in the Diagnosis and Evaluation of ED

Here's some information to help you get ready and know what to expect from your doctor. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. Your surgeon may suggest a lubricant for your partner.

Unfortunately, our website is currently unavailable in most European countries. Depending on the cause and severity of your erectile dysfunction and any underlying health conditions, you might have various treatment options. 5 mg to 1 mg, well below any toxic levels. Also, since the needle hole is very tiny, very little bruising or bleeding occurs. Randomized controlled trials have shown that alprostadil increases the proportion of men who are able to achieve a successful erection compared with papaverine but have not found a significant difference in erectile response compared with bimix. He is also an active member of the Sexual Medicine Society of North America, the International Sexual Medicine Society, the European Society of Sexual Medicine, the International Continence Society, and the American Urologic Association. Wipe the injection site with a new alcohol swab.

Remove the needle. You should not stop taking any prescription medications, unless told to do so by your doctor. Postmarketing studies are continuing. Pull it straight out. In summary, the long-term effects of intracavernous injections are unknown. Iron spell iron key, the patient is then exposed to the steam. If you aren’t treated quickly, it’s possible that you will end up with permanent ED.

  • Phentolamine, when used in higher dosages, has the ability to lower the blood pressure of the body.
  • Six ½ inch, 29 gauge (0.)

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Patients are then monitored, and doses are adjusted as needed. Keep each urethral pellet in its original foil pouch until you are ready to use it. Hold the syringe close to the needle with your thumb, index (first) and middle (second) fingers. This treatment has evolved at the Center for Sexual Medicine over the past twenty years. They have kept him on all the drugs.

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The largest published trial of sildenafil evaluated efficacy based on the previously validated International Index of Erectile Function. Keep in mind that not all men will experience these side effects. Some alternative products that claim to work for erectile dysfunction can be dangerous. Figure 1 Open in figure viewerPowerPoint (A) Proper injection technique demonstrated at the 3 o'clock or 9 o'clock position. This temporary nerve dysfunction is thought to result in structural changes to penile tissue due to prolonged hypoxia. A small nodule or lump may develop if the same site is injected over a long period of time. Or you can use it as suppository, placing it into the opening at the tip of the penis.

Be careful not to pull the syringe out as you’re injecting the medication. After men complained of, and were admitted for, priapism after using oral ED medications, doctors and pharmaceutical companies are required to list prolonged erections as a potential side effect. Read next, “The introduction of a cardiovascular routine 30 minutes, three times weekly can improve erectile function by the equivalent of a half of a Viagra,” says Dr. The needle should be facing the floor. Mobile Apps

You will be trained by your health professional on how to inject, how much to inject and how to safely raise the drug's dosage if necessary. Alprostadil's mechanism of action involves blockage of alpha‐1 receptors, causing relaxation of cavernous and arteriolar smooth muscle and restriction of venous outflow. As of this writing, the drug cost to pharmacists is approximately $263 for 30 tablets of any size. You must replace the amount of medication you remove from the vial with air. The majority of these published data comes from uncontrolled, retrospective studies using various ICI agents and formulations, but there have been two controlled, prospective studies conducted on alprostadil safety and efficacy. Twenty‐nine percent (47 of 162) of participants reported pain on injection at some point during the study, and 11.