Statins and Erectile Dysfunction (ED)

People usually think she’s in her 20s. Many recent studies have attempted to link the growing incidence of erectile dysfunction with other causes, especially in patients suffering from cardiovascular diseases. Statins can not only lower cholesterol, but can improve erections, according to research presented at the European Society of Cardiology Congress in Rome last week.

We have recently read with great interest Dr.

It’s now a symptom of potential, critical heart problems. Possible links to ED While ED isn’t a widely reported side effect of statins, researchers have explored the possibility. Before statin therapy, no correlation was observed between IIEF score and any individual cardiovascular risk factor. All of the studies were considered to be of high quality and used standardized ED assessments like the International Index of Erectile Function (IIEF).

Medical problems that lead to a statin prescription might also be to blame for changes in sexual function, said Dr. The researchers studied databases of published literature to identify studies that had assessed the effects of statin therapy on erectile dysfunction. And even that last one of muscle/joint pains has come under fire. Assessments were carried out before treatment, after treatment and every two weeks during treatment. The difference of 28 cases versus 37 between the 2 groups was not significant ( Scandinavian Simvastatin Survival Study Group, 1994 ). That just leaves the little problem of what to tell men when statins are needed. Of course, statins are not recommended solely for the treatment of erectile dysfunction in patients with healthy cholesterol levels.

In diabetic rats, atorvastatin ameliorated the erectile response to electrical stimulation of the cavernous nerve and normalized the sildenafil effect on erectile function, strongly decreased by diabetes.

Statins Worsen the Quality of Erection

Side effects, according to the Mayo Clinic, include: Neither has happened in our 20 years together and certainly isn’t true now. Laboratory studies, approximately 30 million American men, or half of all men ages 40 to 70, have ED, or trouble achieving or sustaining an erection, the researchers said. In this study, the authors evaluated 2 groups of patients:

None of the other clinical or biological data were significantly different (Bruckert et al, 1996).

Primary Sidebar

The study was carried out by researchers from Tanta University in Egypt and was funded by the same university. An important note on statins is that while they reduce cholesterol being made by the body, they do NOT remove any blockages already in existence. Golomb found that when patients complained about the most commonly recognized side effects of statins, their doctors denied the possibility of a connection more than half the time. 4 points in men who took statins, which is equal to a 25% increase in overall sexual function.

Thus, the CRP test might be less sensitive. Men with erectile dysfunction may see improvements in their sexual ability while taking cholesterol-lowering drugs, according to research. Bmg on wiki answers, case studies about biking and ED have been reported as early as 1975 (3). (5 to six months), and patient types.

Research in 2020 suggested that statins might actually cause erection problems by lowering testosterone levels.

Contact Information

What is going on? It was meant as a treatment for angina. Regulatory agencies in Australia and the UK had yellow card reports of erectile dysfunction in men on lipid lowering drugs, both fibrates and statins. 5 alternatives to erectile dysfunction drugs, read this Patient Information before you start taking sildenafil 20 mg (Revatio) and each time you get a refill. 3), simvastatin (aROR = 2.

Statins are often prescribed to reduce LDL cholesterol levels. The lowest prices of the international questionnaire indicate significant erectile dysfunction. Therefore, this build-up of plaque can affect blood flow to the penis, just as it would affect blood flow to the heart, sometimes causing or worsening erectile dysfunction. Timm medical stayerec impotence ring, super soft, disposable, any such claims are purely anecdotal. Mechanisms of action of ED with statins have not been established but are believed to be due to statin-associated cholesterol suppression, resulting in insufficient levels for normal sexual hormone - primarily testosterone - production.

The mean delay of onset of erectile dysfunction after starting a statin, known for 19 cases, was 62 days with a median of 29 days. In this trial, patients were randomized to receive 20 mg of simvastatin (n = 21) or placebo (n = 20) daily for 6 months and subsequently 10 mg of vardenafil on demand for 4 weeks. Earlier clinical studies reported that atorvastatin showed a 7. Featured topics, a Therapeutic confirmatory study to assess the safety and efficacy of Zydena®(Udenafil) for the treatment of erectile dysfunction in male patients with diabetes mellitus. Many of us may try other drugs in the same class, which is commonly an exercise in futility. Pleiotropic effects of statins are well known regarding the increase of endothelial function.


The increase in IIEF with statins was approximately one‐third to one‐half of that previously reported with phosphodiesterase‐5 inhibitors and larger than the effect of lifestyle modification. The search included the following databases: EDT in Hall C. Major risk factors for erectile dysfunction include diabetes, smoking, drug and alcohol abuse, overweight, depression, stress, heart disease and certain medical treatments. After 10 weeks of intraperitoneal injection of streptozotocin (35 mg/kg), groups I and S received insulin (10 U of NPH/day) for 4 weeks. The IIEF‐5 score was significantly higher after sildenafil treatment than in the atorvastatin treatment group, and the IIEF‐5 score after combined treatment was significantly higher than in the sildenafil or atorvastatin treatment groups ( Gokkaya et al, 2020 ). You can learn more about salsalate as well as home remedies for joint pain and inflammation from “Graedons’ Guide to Alternatives for Arthritis.

3 (the highest score is 30).

Basic Results (scientific)

(4) but not for pravastatin and fluvastatin (Do et al, 2020). Eleven randomized controlled trials in which ED was assessed were identified from the 186 results of a search conducted by the authors of Medline, Web of Knowledge, Cochrane Database, and ClinicalTrials. Log in, to help dissolve the suppository, roll your penis between your hands for 10 seconds. Then, penile tissues were processed for molecular assessment. What mechanisms can explain this last hypothesis? ” To order a copy, send a check for $16 to Graedons’ People’s Pharmacy, Dept. Why statins may not be the cause While researchers have looked into the possibility of statins as a cause for ED, other evidence has suggested otherwise.

Furthermore, Mayo Clinic states that clogged arteries can cause ED. While the study suggests that a statin-like drug may be of some, apparently limited, benefit for men who fail to respond to sildenafil, it certainly does not show that “Statins [are a] cheap and effective treatment”. That’s not to say there aren’t more serious potential complications with statin use.

  • These include those in the penis.
  • You may just need to start living healthier.


For example, someone with atherosclerosis may experience ED as a symptom of their condition. This difference was statistically significant. This one concluded that statin use did not seem associated with a new onset of erectile dysfunction. Except that while erection problems can be due to narrowed blood vessels, they are most often caused by stress, smoking or drinking too much alcohol. Cardiovascular risk factors and treatments were assessed before initiation and after 6 months of statin intake. Scores rose on average for those on statins from 11. There are two main types of cholesterol: I believe that this beta blocker is raising my blood sugar.

Subgroup analyses revealed trends in the atorvastatin group to indicate that a change in the IIEF‐5 score is affected by age, severity of ED, and baseline serum levels of LDL. 15 after six weeks. The main findings in the literature concern atorvastatin, in particular, because statins and sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5i), can activate the nitric oxide (NO) cyclic guanosine monophosphate pathway. The etiology of this condition is multifactorial but it is usually attributed to vascular lesions caused by endothelial dysfunction. Taken together, activating NOS by atorvastatin was expected to be the major mechanism responsible for increasing NO bioavailability. Bbc viewers slam coronavirus news report as presenter 'touches her face' on air. Rarely, statins can cause liver damage. Previous research has suggested a negative association between statin therapy and testosterone levels, leading to questions about the effects of these widely used medications on the quality of erection. The authors report that a major limitation of the study was that they did not assess whether sildenafil (Viagra) was effective as a follow-up treatment for erectile function after therapy with atorvastatin (Lipitor) or vitamin E.

Why the Coronavirus Pandemic is Much More Dangerous Than It Truly Is

Speaking at the European Society of Cardiology (ESC) Congress in Rome, lead researcher Alexios Samantzas from Elpis Hospital in Athens, Greece, said the results were “very significant”. Clinical findings displayed that atorvastatin increased the IIEF-5 score and improved both tip and base rigidity by Rigiscan, indicating a real improvement in erectile function tests. 1%) had ED, whereas 431 (0. The study was presented here today at the American College of Cardiology (ACC) 2020 Scientific Sessions and simultaneously published online in the Journal of Sexual Medicine[1]. Although two of these studies showed no statistically significant improvement in erectile function with use of a statin, they both showed potential in statin use with a larger improvement for men with more severe ED compared to men with a lesser degree of ED. Kostis said that larger randomized controlled trials are needed to further investigate the link between statin therapy and erectile function. Ebbert is professor of medicine and a primary care clinician at the Mayo Clinic in Rochester, Minn. In 2020, a study was done by the West China Hospital in Sichuan University that concluded that use of statins reduced testosterone levels.

(7%) responded to a questionnaire about sexual function at a mean posttransplant time of 5. Apart from this brief explanation of people who dropped out of the study, no other information is provided about the side effects associated with taking this drug, despite the fact that the authors report that side effects were assessed fortnightly. Based on these studies, the use of statins for treatment for ED cannot be justified. One prescription option that often is overlooked is the drug salsalate. They are effective, which is why cardiologists prescribe them for their patients at risk for heart attack, coronary heart disease, angina and stroke.

Neither blood pressure lowering with candesartan/HCTZ nor cholesterol lowering with a statin showed an impact on erectile function. I recently had my cholesterol checked again, and it has dropped all the way to 111. In addition, some patients taking atorvastatin achieved a response of 5 to some questions, but none of the participants regained normal erectile function (IIEF-5 score <22). A systematic review by Rizvi and colleagues ( 2020 ) showed that a substantial number of cases of ED associated withstatinusagehavebeenreportedtoregulatoryagencies. (18] for each decrement of total testosterone and calculated free testosterone, respectively). Lead researcher Dr Alexios Samentzas said: Another important message was obtained from the French Pharmacovigilance System Database, with which the case/noncase method was used to measure the disproportionality of combinations between statins and ED.

The researchers state that the increase seen was equivalent to about one-third of the improvement seen with phosphodiesterase 5 inhibitors (which include Viagra).

Publication History

Systematic review of three English language randomized controlled trials published between 2020-2020. “The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra,” said John B. Reply via e-mail at [email protected] In the end, six studies involving 462 patients met their inclusion criteria.

Recommended for You

Previous preclinical animal studies supported the improvement in both erectile function and eNOS by atorvastatin through the inhibition of Rho/Rho-kinase contractile mechanisms of the penis. First published online: Diclofenac can be irritating to the digestive tract. This could then increase the flow of blood to the penis.

  • “Statins could be a cheap and effective treatment for erectile dysfunction,” reports the Daily Mail.
  • The investigators also remind us that PDE5 inhibitors are palliative, not curative.
  • The ACC’s Annual Scientific Session brings together cardiologists and cardiovascular specialists from around the world each year to share the newest discoveries in treatment and prevention.
  • And with the amount of money that patients shell out for these drugs, we should not be surprised.
  • The results of a recent randomized, double‐blind, placebocontrolled clinical trial (Simvastatin treatment for erectile dysfunction trial) did not support the use of simvastatin as an erectogenic medication (Mastalir et al, 2020).

Rights And Permissions

21 Further studies may be required to investigate the effects of rosuvastatin on erectile function of sildenafil nonresponders. In other research, Dr. The study included 100 male patients (aged 40–70 years) with unique risk factor dyslipidemia (none of them was receiving lipid-lowering treatment) and erectile dysfunction. Common causes include heart disease, high cholesterol, high blood pressure, diabetes, obesity, tobacco use, depression and stress. 13, 95% CI = −1. In the study presented at the 63rd Annual Scientific Session of the American College of Cardiology and published in Journal of Sexual Medication March 29, the researchers sought to determine the effects of statin on erectile dysfunction by conducting a meta-analysis of 11 earlier studies on ED and statins involving about 640 men. This effect of statin therapy in patients with ED remains controversial as LDL-C lowering may affect the lipid precursor for testosterone. At baseline, the 2 groups had no significant differences, including IIEF‐5 scores, but after treatment, group 2 had a significantly higher postoperative IIEF‐5 score than group 1 at 6 months postoperatively.

Common Conditions

GoodRx is not available outside of the United States. Finally, 15 patients were also receiving other drugs, and 3 had diabetes (Carvajal et al, 2020). Simple relaxation techniques, , 2020 Erectile dysfunction and decreased libido Low Level of Evidence Confounding Factors Discontinuation NOT recommended (benefit of antiretroviral therapy +++) Antihistamines Cimetidine (Van Thiel et al. Regarding atorvastatin, it was found that atorvastatin interfered with the oxidation process, leading to the reduction of circulating markers of oxidation. There are several risk factors for developing ED, and high cholesterol can be one of them. Two studies in the review show an insignificant improvement in erectile function of participants taking a statin vs.

But discontinuation rates approach 50%, with most men citing lack of consistent efficacy as the cause for stopping. We are only now beginning to realize the wide-ranging importance of cholesterol in human physiology. The scores were then categorised into five categories – severe, moderate, mild-to-moderate, mild and no erectile dysfunction. After 6 months of statin administration, lower IIEF scores correlated significantly with age or diabetes and weakly with cigarette smoking (Solomon et al, 2020).

How many men suffer from erectile dysfunction? Exercise more. Heart disease often occurs when there is a build-up of plaque in the arteries, which decreases blood flow to the heart, brain and rest of the body.


We continue to identify technical compliance solutions that will provide all readers with our award-winning journalism. The study’s authors note that oxidized LDL inhibits vascular smooth-muscle relaxation. 7 million, according to the federal Agency for Healthcare Research and Quality. 4. spinal cord injuries, according to the manufacturer, one pill should be taken every day for 6-8 weeks. My cholesterol was elevated to 290, so my doctor prescribed atorvastatin. Salsalate may not reduce the chance of cardiovascular problems, but it doesn’t seem to increase the risk either (JAMA Cardiology, July 1, 2020). Physiology of erection is mainly dependent on endothelial NO-production with consecutive activation of guanylate-cyclase. 0% (one out of every one hundred Zocor users); atorvastatin (Lipitor) was 1.

It seemed to do very little for the heart condition but trial volunteers reported they were getting a lot of erections.

Box 52027, Durham, NC 27717-2027. 8 million people to 29. In a highly publicized meta-analysis, presented at the American College of Cardiology Scientific Sessions 2020 and simultaneously published in The Journal of Sexual Medicine, statin therapy was shown to improve lipid profiles as well as ameliorate ED in 647 men who had both conditions. The analysis of protein expression levels suggested elevation of RhoA and Rhokinase in obese diabetics and a lowering of Rho‐kinase II with statin treatment; then, the RhoA and Rho‐kinase II mRNA levels were significantly reduced in the rosuvastatin‐treated obese diabetic animals ( Wingard et al, 2020 ). Another important aspect concerns the modulation of endothelial function carried out with the use of statins. Some docs are sceptical about the pills as they can cause debilitating side effects, including muscle pain.

Countries Of Recruitment

8 years; statin therapy was given for approximately 4 months with a mean decrease in LDL-C in treated men that ranged from 138 mg/dL to 91 mg/dL (47 mg/dL). LDL cholesterol is the type that causes problems. In a more complete evaluation of endothelial function, we know that one of the earliest recognizable effects after treatment with statins is the restoration of endothelium‐dependent relaxation ( Anderson et al, 1995 ); moreover, inhibition of endothelial HMG‐CoA reductase up‐regulates endothelial nitric oxide synthase (eNOS) expression, predominantly by posttran‐scriptional mechanisms ( Laufs et al, 1998 ). All had a temporal sequence.

Men who took statins (+/- sildenafil) generally saw their IIEF scores improve, indicating better erectile function.

Our findings suggest that these two medications do not negatively impact erectile function, which should be reassuring to men who are taking them.

Log in to Wiley Online Library

However, a new study into the effects of cholesterol-lowering statins and blood-pressure lowering candesartan/HCTZ concludes that these medications do not negatively affect erectile function. Despite the study's findings, Kostis said he does not recommend taking statins for improving erectile function in men who do not have high cholesterol. The association between ED and statins was evaluated by calculating the reporting odds ratio (ROR) of exposure to each drug and its 95% confidence interval. It is unclear how statins may improve erectile dysfunction, but the researchers speculate that it may be due to decreased levels of LDL cholesterol and improved endothelial function – which includes the ability of blood vessels to dilate and constrict. “Participants experienced a 43% improvement in their erections, the effect is around half that of sildenafil [Viagra]. But the big question you want answered is can statins cause ED? There is tentative evidence that cholesterol reduction with statins can also help erectile function.

88, 95%CI = 3.

Although statins are not recommended as primary treatment for erectile dysfunction in men with normal cholesterol levels, this effect could improve compliance in hypercholesterolemic patients treated with statins. The causes of erectile dysfunction and heart disease are very similar. And patients do not have to take specific drugs for erectile dysfunction. So, by deductive reasoning alone, anything that prevents that blood from flowing (i. )

Would that restore my ability to get an erection?

4% in group 1 ( Hong et al, 2020 ). OUTCOMES MEASURED: Also, a systematic review revealed that statins may cause ED []. A study duration of 6 weeks was a sufficient period for atorvastatin or vitamin E to show response. National, , has a half-life of 17. Statins and male sexual health: Finally, statins represent a stimulus for the release of endothelial progenitor cells, probably through the up‐regulation of metal‐loproteinase 9 ( Asahara et al, 1999 ; Figure ). In this study, authors examined the intracavernous pressure: Your doctor should be able to prescribe a medicine that won’t increase your risk for diabetes.

Resource Topics rightRail

Therefore men using statins to improve their cholesterol levels may emerge a significant improvement in erectile function. Millions of Americans are prescribed statins to prevent heart disease, but some stop taking the medication or take less than the prescribed dose, Kostis said. The increase in erectile-function score was about one-third to one-half of that reported with phosphodiesterase inhibitors, such as sildenafil (Viagra, Pfizer), tadalafil (Cialis, Lilly), or vardenafil (Levitra, Bayer/GlaxoSmithKline), and larger than the effect of lifestyle modification or testosterone, Kostis said. Concurrently, group S received simvastatin (20 mg/kg daily). Choose your country or region, maintain a healthy weight. This effect remained statistically significant after multiple sensitivity analyses, including analysis for publication bias, a cumulative meta‐analysis, and 11 repeated analyses with each study omitted sequentially. Do lipid-lowering drugs cause erectile dysfunction? The assessments included erectile function tests as well as other biochemical and blood tests.

  • However, despite this improvement, none of the men in the atorvastatin group had an erectile function score within the normal range at the six-week mark (a score less than 22 was considered to indicate erectile dysfunction).
  • Their meta-analysis examined studies that compared statins (+/- sildenafil) with a placebo (+/- sildenafil).
  • This research includes a meta-analysis adding up results from 11 randomised controlled trials that found a 24.
  • RigiScan measurements were compared before and after treatment with atorvastatin (mean length of treatment was 3.)
  • 4 points (95% CI 1.)
  • On the flip side, statins can cause side effects such as fatigue and muscle weakness.
  • Get tested and see a doctor.

You Are Here

In the Scandinavian simvastatin survival study, 4444 patients with coronary heart disease were randomized to treatment with simvastatin or placebo for up to 6. There are some limitations to this study, some of which are described by the authors: Men prescribed cholesterol-lowering statins may have an extra reason to take their medication, according to research linking statins to improved sexual function.

After analysis, researchers found that men with erectile dysfunction who were taking statins for high cholesterol saw a significant increase in sexual function.

Site Navigation

However, larger controlled studies for longer durations may be needed to establish the real cost-effectiveness of such a combination. Metaregression showed an increase in benefit with decreasing lipophilicity. Results showed a total of 60 cases of erectile dysfunction. In this article, Dr. In the first meta-analysis of previous studies on erectile dysfunction and statins, researchers identified 11 randomized, controlled trials that measured erectile function using the International Inventory of Erectile Function – a self-administered survey with five questions, each scored on a five-point scale and totaled, with lower values representing poorer sexual function. In the first subgroup patients received a statin (atorvastatin) while the second subgroup received no treatment (control group). One of the first studies investigated whether pretreatment with atorvastatin (0, 5, and 30 mg/kg per day) for 2 weeks affects sildenafil (1 pM to 100 mM)‐induced relaxation of aortic rings isolated from Wistar rats, as well as the hemodynamic consequences of this interaction in vivo. 4 points, from 14.

The researchers found that statin has a significant impact on erectile dysfunction in men with high cholesterol levels and ED. The effect was apparent by 6 weeks ( Herrmann et al, 2020 ). Currently, the number of molecules available have a similar chemical structure, although differing in pharmacokinetics and drug interactions ( Sweetman, 2020 ; Table ). One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic compared with matched controls. How statins help improve erectile function is possibly similar to how Viagra, a popular prescription drug for erectile dysfunction, works. I am now on diclofenac and take Nexium (40 mg) for GERD.