Edex (Alprostadil for Injection): Uses, Dosage, Side Effects, Interactions, Warning

Hold the needle assembly (still in the paper wrapper). Membership, erectile dysfunction can cause strain on a couple. Make sure a new, correct strength vial of CaverJect is used for each patient dosage preparation. Quickly push down on the plunger to inject the medication into the shaft of your penis.

  • The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose.
  • The erection will last 30 minutes to an hour or up to orgasm.
  • However, due to efficacy, cost, and side effects, it is not used often.

‌​ Read this resource carefully before starting injection therapy. Extracorporeal shock wave therapy (ESWT) - low-intensity shock waves that aim to fix the erectile tissues and help restore natural erections. Penile injections must be self-administered, meaning you inject them yourself. Find an injection site on one side of your penis, in a place with no visible veins. Never more than once in any 24 hour period. Share, what does this mean? We continue to identify technical compliance solutions that will provide all readers with our award-winning journalism.

Men most often start having sex with their penile implants by eight weeks after surgery. Invicorp may work well for men who have found little success with other ED treatments and some may find it less uncomfortable to use than alprostadil injections. I also have seen an electrophysiologist (in 2020) who was not inclined to recommend this test.

  • Withdrawing the medication Pull the plunger down past your prescribed dose.
  • If you smoke, quit.
  • There is a possibility of needle breakage with use of CaverJect.
  • Maximum dosages when prescribed as monotherapy range from 30 to 40 μg, with the most commonly used doses between 10 and 20 μg.
  • If you’re using the medication for the first time, take the cap off.
  • Phentolamine, when used in higher dosages, has the ability to lower the blood pressure of the body.


If an erection is painful or persists for more than 3 hours the following treatment should be commenced. Do not share your needles or syringes with other people, even if the needle has been changed. We focus exclusively on protecting the injured, so you can rest assured that we truly understand how to help. More and more often doctors are prescribing penile injections for patients who don’t actually need them. Remember to avoid any veins.

We are engaged on the issue and committed to looking at options that support our full range of digital offerings to the EU market. A total of 153 men with ED with a mean age of 53 years (range 23–69 years) were enrolled. 16/32 [50%] with trimix; P < 0. Ideally, the injection should be administered just prior to foreplay. Be careful not to bend the needle.

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8 Mixed <25 cm/s >6 cm/s <0. This is so you don’t inject into a nerve or blood vessel. Hold the injection device as shown in Figure M.

  • With the needle cover in place, set the syringe and needle down on a clean, level surface, like a table.
  • Alprostadil usually begins to work in about 5 to 10 minutes.
  • 6 μg + phentolamine 0.
  • A convenient carrying case is provided for the reusable edex® (alprostadil for injection) injection device.

What Drugs Are Used?

If you’re using Bimix or Papaverine, you don’t need to keep your medication in the refrigerator. The 3 most commonly used medications for injection therapy are Trimix, Bimix, and Papaverine. CaverJect may cause serious side effects, including: Like us on Facebook: Advise patients to insert the needle perpendicular to the long access of the penis to avoid bending or breakage of the needle [see Dosage and Administration (2. )Instruct the patient on proper use and assess that they are well trained in the self-injection technique prior to initiation of home use.

The following supplies are needed for injection and are not supplied with CaverJect: There is a paucity of data directly comparing the efficacy of the various vasoactive ICI agents 50-55. Papaverine and phentolamine also belong to this group of medicines called vasodilators (drugs that relax smooth muscle tissue, causing arteries to open and allowing an influx of blood flow). Know the medicines you take. Discomfort, bruising and swelling after the surgery will last for a few weeks. Your doctor may point out ‘risk factors' that can be changed or improved.

Penile Fibrosis

Older age, younger partner age, and fully rigid erections were predictors of increased satisfaction 65. The main surgical treatment of ED involves insertion of a penile implant (also called penile prostheses). Using the correct strength vial containing 20 mcg or 40 mcg of CaverJect, use a 1 mL to 3 mL syringe, a 21 to 27 gauge needle and 1 mL of the diluent (bacteriostatic water for injection preserved with benzyl alcohol 0. )Rarely, your erection may last too long (see the section below ‘What if my erection lasts too long? )Alprostadil self-injection.

This can easily be achieved by pushing in your wheelchair for approximately 20 minutes.

Today, CPDU is not mandatory in the initial evaluation of ED patients due to the effectiveness of oral PDE5 inhibitors in treating ED of multiple etiologies; however, it can be helpful in directing therapy for patients with suboptimal responses to PDE5 inhibitors 13-16. What should you tell your partner? There is better than an 80% chance that self-injection therapy utilizing vasoactive drugs is an effective treatment. A total of 296 men with ED with a mean age of 54 years (range 21–74 years) were enrolled in this double-blind, placebo controlled, parallel-arm design study.

Second-Line Therapy: Intracavernosal Injection Treatment

Based on the available data, alprostadil is thought to be the most efficacious monotherapy, while trimix is associated with the highest overall efficacy, with reported response rates as high as 92%. In this case, testosterone replacement therapy might be recommended as the first step or given in combination with other therapies. If you have an account, please sign in. Life cycle of a penis, these exercises target the muscles at the bottom of the pelvis, and particularly one called the pubococcygeus. Alprostadil is bound in plasma primarily to albumin (81% bound) and to a lesser extent α-globulin IV-4 fraction (55% bound). Inform the patient that injection of CaverJect can induce a small amount of bleeding at the site of injection and that hematoma and ecchymosis may occur. Ask what you need to do ahead of time. Do not use the solution if it is cloudy, colored or contains particles. It is safe for patients who are taking Aspirin, Persantine and Coumadin.

How often can the injections be used? The typical vacuum device consists of a plastic cylinder, a tension ring, and a small hand pump. This is the same as a chemical that the penis produces naturally when it becomes erect. Proper education is key. If the needle breaks during injection and you are able to see and grasp the broken end, you should remove it and contact your healthcare provider. Penile pain was reported by 50% of the study participants, but pain occurred after only 11% of injections (1,873 of 16,575), indicating that pain typically did not occur after every injection. To maintain sterility and avoid contamination, follow these directions carefully.

3% for a cohort of 596 men regularly using ICI therapy. Your doctor will ask you about your medical history and your symptoms to devise an ED treatment plan that is right for you. This treatment has evolved at the Center for Sexual Medicine over the past twenty years. Even when you have demonstrated the ability to undertake home injection therapy, you and Mr Katz will continue to liaise after each injection until the desired result is achieved. You then remove the vacuum device. Do not transmit information of a private or personal nature. Separate needles should be used for reconstitution and administration. Impaired vascular endothelial function causes decreased production of nitric oxide and insufficient relaxation of smooth muscle within the cavernosal bodies 7, 8.

These medications might not treat your erectile dysfunction immediately.

How to Get Started

Before taking any medication for erectile dysfunction, including over-the-counter supplements and herbal remedies, get your doctor's OK. Prolonged erections greater than four hours in duration occurred in 4% of all patients treated up to 24 months. Go to MSK’s Urgent Care Center if you’re less than 30 minutes away. Priapism is the most serious adverse side effect associated with papaverine and is seen in 3–18.

Most often, one small surgical cut is made. Related articles, prostate gland enlargement rarely causes signs and symptoms in men younger than age 40. Involve your sexual partner. To prevent trauma to your penile tissue, always change sides of your penis each time you inject the medication (right side, then left side).

You should receive your first dose of CaverJect in your healthcare provider's office. What are the Side Effects? 2% (2 of 162) of participants. 4765 or fill out our contact form to reserve a free consultation with an attorney who cares about your future. Do not inject within 72 hours (3 days) of taking tadalafil (Cialis) 10 mg or 20 mg.