Genetic Risk Factor Associated With Erectile Dysfunction

You may find that doing such changes can help to improve getting and maintaining an erection. The new findings could change that. Goldstein noted that a drug called bremelanotide, currently under review at the Food and Drug Administration (FDA), reportedly can reduce sexual dysfunction in women by targeting and activating those melanocortin pathways. The researchers conducted a genome-wide association study in two large and diverse cohorts to investigate genetic contributors to the risk of erectile dysfunction. Kerns SL, Stock R, Stone N, Buckstein M, Shao Y, Campbell C, Rath L, De Ruysscher D, Lammering G, Hixson R. It is too soon to say if this is a causal relationship. SIM1 encodes a transcription factor involved in both sexual function and body weight regulation, and the authors note that several lines of evidence suggest that the SIM1 locus is involved in regulating the gene.

  • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.
  • “Our paper echoes recent findings that the cause can be genetic, and it goes further.
  • Scientists haven’t figure out yet the relation between the thyroid hormone and ED.
  • Gene therapy possible Goldstein, however, does see a potential path to genetic therapies.
  • The location is near the SIM1 gene, which is thought to be related to obesity.
  • Millions of men struggle with it, but shockingly few ever seek treatment.
  • In fact, men experiencing continuous erectile dysfunction can have depression (depression and erectile dysfunction often co-exist).

Neurotrophic factor 3 3. The treatment, that works similarly to a vaccine, is a combination of two existing drugs, of which tiny amounts are injected into the solid bulk of a tumour. Nonetheless, Shoskes called the study’s findings “valid and very interesting, and a starting point for new research,” specifically looking at the genetic locations identified. The ED-linked genetic location found in the new study was a location on chromosome 6 near a gene called SIM1. Erectile dysfunction could be caused by hormonal, neurological or vascular changes. If a problem develops with any of these things, erectile dysfunction could be the consequence.

  • 36 per 1 SD genetic increase in insulin resistance (P =.)
  • 5 million Britons found that even “metabolically healthy” obese people are still at a higher risk of heart disease or a stroke than those with a normal weight range Getty 35/40 Sleep deprivation When you feel particularly exhausted, it can definitely feel like you are also lacking in brain capacity.
  • Other physical disorders, as well as hormonal imbalances and certain operations, may also result in erectile dysfunction.
  • Study data suggests it affects 18 million men over the age of 20 in the United States.


Montorsi F, Luigi GG, Strambi LF, Da Pozzo LF, Nava L, Barbieri L, Rigatti P, Pizzini G, Miani A. Surgery – One of the more invasive treatments for erectile dysfunction, surgical options also exist. Before you start a course of treatment, be sure to tell your doctor about any drugs or supplements you may be taking and keep an eye out for side effects. Nephron 25/40 Babies' health suffers from being born near fracking sites, finds major study Mothers living within a kilometre of a fracking site were 25 per cent more likely to have a child born at low birth weight, which increase their chances of asthma, ADHD and other issues Getty 26/40 NHS reviewing thousands of cervical cancer smear tests after women wrongly given all-clear Thousands of cervical cancer screening results are under review after failings at a laboratory meant some women were incorrectly given the all-clear. EGCUT received funding from the European Commission Horizon 2020 research and innovation program.

However, there are some things you can do to help reduce it or even stop it – especially if it is not because of a serious underlying condition. She waited until she had threaded the fine needle before she explained. The study was published Oct. UCSF Health has affiliations with hospitals and health organizations throughout the Bay Area.

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In many cases, the common causes of erectile dysfunction do not run in families. Here is a sampling of key outlets. If you’re ready to stop living in embarrassment about your sexual function, become an advocate for yourself and your own health and talk to your doctor.

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“Hopefully, this will translate into better treatments and, importantly, prevention approaches for the men and their partners who often suffer silently with this condition. It’s a big deal, study co-author Eric Jorgenson, Ph. Share on Pinterest Future treatments could target specific genes as a treatment for erectile dysfunction. Their study, published in the Proceedings of the National Academy of Sciences, shifts the focus from symptoms and attempts to identify their cause, which appears to be a single area on chromosome 6 that seems to control whether or not a guy will continually struggle to get it up, even if he doesn’t have other risk factors, like high body weight or alcohol and cigarette use. Besides, genes are not destiny. Having a thymine (T) nucleotide at this position increases the risk of erectile dysfunction by around 25 percent, the researchers found, after taking into account other risk factors for the disorder.

Asparagine, a molecule named after asparagus where it was first identified in high quantities, has now been shown to be an essential ingredient for tumour cells to gain these migratory properties.

Thai, of Kaiser Permanente Northern California; Melody R. He noted that about 50 percent of men do not respond to erectile dysfunction treatments currently available. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with the development of erectile dysfunction following radiation therapy for prostate cancer.

On this trajectory that could rise to nearly 200,000 excess deaths by the end of 2020, even with the extra funding that has been earmarked for public sector services this year.

So one thing to help the sufferer from perhaps feeling less guilty about it (as some men do) is to understand the causes of erectile dysfunction and identify what could be causing it. A gene could be thought of as a light bulb, Jorgenson explained, and the promoter is akin to its switch, while the enhancer is like the fuse box. Co-lead author Professor Michael Holmes, of the University of Oxford, said: However, this research is still continuing, and nothing has been proved until yet. The new research pinpointed a specific place in the human genome that’s tied to a greater risk of ED. Contact us, these penile injections can be especially useful when patients are unable to take PDE5 Inhibitors because they are taking nitrates, certain beta blockers, or experience severe side effects from the oral medications. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. So, don’t blame your parents if you’re having problems in bed. The mutation of this gene has been now linked to impotence.

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The cohort included 36,648 men who had been diagnosed with ED. But despite the effectiveness of treatments such as Viagra, many men cannot be helped. The prevalence of ED, which was determined on the basis of self- or physician-reported ED, the use of oral ED medication, or a history of ED surgical intervention, was 1. Originally published on Live Science. Other support was provided by NIDDK Grant 1R01DK090382 and a UCSF School of Pharmacy 2020 Mary Anne Koda-Kimble Seed Award for Innovation, National Human Genome Research Institute Grant 1UM1HG009408, NIMH Grant 1R01MH109907, National Institute of Child and Human Development Grant 1P01HD084387, and National Heart, Lung, and Blood Institute Grant 1R01HL138424.


Erectile dysfunction. The genetic codes of men with or without impotence were thoroughly searched to check for differences. In these men, they identified a spot along the sixth chromosome that was associated with an added risk of erectile dysfunction. The first cohort came from the Genetic Epidemiology Research on Adult Health and Aging cohort, part of the Kaiser Permanente Research Program on Genes, Environment and Health. 8, 2020 (HealthDay News) -- Scientists report they have uncovered the first evidence that erectile dysfunction may have genetic underpinnings. Now, a new study has suggested this could be because chronic sleep deprivation can actually cause the brain to eat itself Shutterstock 36/40 Exercise classes offering 45 minute naps launch David Lloyd Gyms have launched a new health and fitness class which is essentially a bunch of people taking a nap for 45 minutes. Goldstein said a version of the drug was also shown to work in men, increasing sexual desire and erection rigidity by targeting the same hormone.

  • In a new study, researchers report that they've found a genetic link for erectile dysfunction.
  • Then, the researchers looked to see if there were any links between a person's genetic risk factor score and ED.
  • The first study used genetic information from the Genetic Epidemiology Research on Adult Health and Aging cohort, a division of the Kaiser Permanente Research Program on Genes, Environment and Health.
  • Drug-induced male sexual dysfunction.
  • Services USDoHaH.
  • It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with nationally renowned programs in basic, biomedical, translational and population sciences; and a preeminent biomedical research enterprise.

Preclinical Gene Therapy

It’s been suggested that genes are a factor in around a third of cases. Italian researchers found women living in the most polluted areas were three times more likely to show signs they were running low on eggs than those who lived in cleaner surroundings, potentially triggering an earlier menopause Getty/iStock 7/40 Junk food ads could be banned before watershed Junk food adverts on TV and online could be banned before 9pm as part of Government plans to fight the "epidemic" of childhood obesity. They also controlled for other common factors in ED like BMI, cardiovascular disease, diabetes and smoking, and found that it remained relevant no matter what additional health risks people had. Scientists might be closer to an answer.

Though the researchers didn’t look at women in this study, they suggest that future research might take a look at the SIM1 gene in females as well. But it’s been difficult to find exactly where this added risk could be in our genome. The researchers, therefore, suggest that a potential mechanism for the effect of the MCHR2-SIM1 locus on ED could be the hypothalamic dysregulation of SIM1. Getty 21/40 Student dies of flu after NHS advice to stay at home and avoid A&E The family of a teenager who died from flu has urged people not to delay going to A&E if they are worried about their symptoms. Jama 2020;291: Here are some of the options: The findings in the GERA cohort were then verified in a cohort of 222,358 men from the U.

Co-first author Dr Jonas Bovijn, also from the University of Oxford, said: So, for each condition, the researchers calculated a "genetic risk factor score," based on the number of risk-increasing gene variants a person had. SBP also had a causal effect on ED risk, at an odds ratio of 2.

Other Treatments

To overcome this challenge, the study looked to see whether the SIM1 locus was a risk factor when considering differences in how men reported their erectile dysfunction to their doctors. To have the best chance of finding a genetic cause, we combined people who self-reported with those taking ED medications such as Viagra, and those who had surgical procedures to deal with ED-related health issues. She was pleased with them! 3 between the MCHR2 and SIM1 genes, with rs57989773 the lead variant.

You might have your father’s eyes, or your mother’s smile or even your grandfather’s face. For men with this genetic variation, ED risk is independent of known risk factors like body mass index, the authors noted. Our study drew upon data in the UK Biobank of men of European ancestry, and we then compared and combined our findings with data of men drawn from the Estonian Genome Center of the University of Tartu, and the Partners HealthCare Biobank in the US in order to draw conclusions from a wider sample. In the current study, researchers in the U. Ask a doctor about trying Viagra today.

In other words, some people may be more likely to develop ED due to genetics rather than only from problems that develop later in life.

  • Sometimes, the inability to get an erection and perform satisfactory sex can have an impact on relationships, adding to the stress a man will probably go through.
  • Because the erectile dysfunction risk locus showed enhancer activity and interacted with the SIM1 promoter, the erectile dysfunction risk locus likely influences the expression of the SIM1 gene, turning it on and off when needed, the study suggests.
  • The study suggests that "having a genetic predisposition to type 2 diabetes … also predisposes you to having [ED]," said co-senior author Anna Murray, associate professor of human genetics at the University of Exeter in the U.

The Bottom Line

SHOULD YOU GET IT? Taking certain medications can also increase your risk for ED. But, in cases where it does appear to be a factor, there is some hope future treatments like this might be able to help.

It is very common to see a combination of psychological and physical causes, but pure psychological causes are seen in less than 1 in 10 (10%) of all affected patients. It makes "good biological sense," Murray added. However, not all doctors are convinced the new research proves that connection. Lifestyle issues, such as obesity, smoking, and stress, are still factors, but this discovery could lead to new genetic treatments. One contained data from 36,648 men that were part of the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort, which is affiliated with the Kaiser Permanente Research Bank. Pilates exercises:, 5% of the men had postmicturition dribble after they had left the toilet. Eating a healthy diet, exercising, and avoiding bad habits such as smoking can lower your risk for erectile dysfunction and other medical conditions. Jorgenson’s follow-up analysis on the actual function of the enhancer on SIM1, shown by previous studies to to regulate hormones crucial to sexual function.

Patient Summary

Wein AJ, Van KNA. Copyright © 2020 HealthDay. Ion channels (K+-Ca+2 systems via hSlo) 3. AAAS/Eurekalert! ED can affect anyone: Variations in the SIM1 locus, the region of DNA containing the SIM1 gene, was associated with a 26 percent increased risk of impotence.

In addition, the prevalence in the UK Biobank cohort may have been affected by a "healthy volunteer" selection bias and a lack of primary care data.

There is no real, hard evidence currently suggesting that erectile dysfunction is genetically linked. They found that guys with a variation on their sixth chromosome, found near the SIM1 gene, had a 26 percent increased risk of ED. According to the figures, one fifth of all men aged over 20 years in the United States suffer from erectile dysfunction. Well, understanding the cause and risk of developing a condition such as ED will help us to think about how we may advise or treat patients. However, what makes the finding particularly interesting is that generally, risk factors for ED are thought to be things that occur alongside diabetes, such as hypertension or elevated body mass index (BMI) — in other words, that ED is the result of conditions that people have in addition to diabetes — not diabetes in and of itself, Messer told Live Science.

Related Questions

When choosing an erectile dysfunction treatment, you should take your time. But our genes matter, too. It has been reported that in some cases, passive smoking can also cause ED.

Other conditions that may contribute to erectile dysfunction include Parkinson’s, multiple sclerosis, Peyronie’s disease, sleep disorders, smoking, alcoholism and drug abuse.

Though each of these categories has its own set of contributing factors, many cases of erectile dysfunction involve causes from both categories. So while you may believe that your erectile dysfunction is because of your genes, it is quite likely that your impotence is not a hereditary problem at all. This again imposes a risk to ED as well.

  • Lue TF, Brant WO, Shindel A, Bella AJ.
  • The new research might open the possibility, for some patients, of a future treatment that targets specific genes in order to reduce inherited ED risk.
  • The finger of suspicion points to a gene called SIM1 which could be a target for new impotence treatments.

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Discuss any issues you have with your partner and when they are understanding of you then you probably will begin to feel good about yourself. This can lead to a feeling of inadequacy and a sense of loss of manhood (called performance anxiety). You are not under any severe medication, which may hit you with an ED or any injection which could be a possible reason for your erectile woes. LDL cholesterol was found to have a minor impact on the risk for ED, at an odds ratio of 1. Heaton JPW, Adams MA. A search was made for genetic differences that occurred more often in men with a history of erectile dysfunction. Think of a gene like a light bulb, Jorgenson said: The location suggested that the condition is associated with dysregulation of the hypothalamus.

It can turn it on and off when necessary. Ideal vector system 5. The researchers initially showed that a region on chromosome 6 is linked to the development of ED. The erectile dysfunction project was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Grant R01 DK104764.

While on the face of it the conditions may seem unrelated, type 2 diabetes can cause nerve damage and problems with blood vessels.

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The UCSF Fresno Medical Education Program is a major branch of the University of California, San Francisco’s School of Medicine. Current treatments aren’t helpful in many cases. Pelvic surgery: – An alternative to oral medications, vacuum constriction devices can create an erection using vacuum pressure — once an erection develops, a constriction band is placed around the base of the penis to maintain the erection. Palmer, PhD, Gail P. The study then identified a biological role for this location in erectile dysfunction susceptibility. Illustration : While well-known drugs like Viagra have been used to great effect for many men with erectile dysfunction, they don’t come without risks.

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UK Biobank is an amazing store of genetic and medical data available to scientists. Certain things that can cause erectile dysfunction may run in families, although the condition itself isn't genetic. In this case, this team believes their enhancer affects a gene called SIM1, which in turn helps ensure that hormones crucial for trigger erections reach their targets in the brain. For specific information about your personal medical condition, please contact our doctors or pharmacists for advice on [email protected].

“New treatments that target this newly identified genetic risk factor have the potential to benefit them.

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What our study has shown is that people with a higher genetic risk of type 2 diabetes were also at higher risk for ED, suggesting that T2D is likely a cause of ED. – One of the more invasive treatments for erectile dysfunction, surgical options also exist. Support for participant enrollment, survey completion, and biospecimen collection was provided by the Robert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, the Ellison Medical Foundation, and the Kaiser Permanente Community Benefit Programs. For example, previous research has identified about 100 gene variations that are linked to type 2 diabetes alone.

Symptoms of Erectile Dysfunction

This new genetic finding may provide an opportunity to develop new drugs to treat ED, to examine how existing medications could be used with patients earlier, or to predict men's chances of developing ED. You are advised to eat a healthy diet and avoid unhealthy habits and talk to a sexologist to lower your risk of erectile dysfunction. So far, the evidence supporting the link between type 2 diabetes and ED has only been observational, meaning that researchers could not establish causality. Cigarettes can contain up to around 41,000 chemicals, some of which that can cause ED, such as, acetone, arsenic and carbon monoxide. We do know what are the possible causes which can be addressed by you or by the doctor – depending on what the cause may be. Although earlier studies of twins have demonstrated that at least a third of ED risk is heritable, until now scientists had never been able to locate a site in the genome that confers this risk.

Diagnosis of Erectile Dysfunction

The researchers also connected the locus to the regulation of sexual function. The independent effects of BMI and ED also suggest that men may be at risk of ED regardless of their weight. Of the men who reported that they “never” were able to get hard, having this gene meant they had 1. Another popular drug, venlafaxine, was shown increase the risk users engaging in suicidal thoughts and attempts at suicide Getty 16/40 Gay, lesbian and bisexual adults at higher risk of heart disease, study claims Researchers at the Baptist Health South Florida Clinic in Miami focused on seven areas of controllable heart health and found these minority groups were particularly likely to be smokers and to have poorly controlled blood sugar iStock 17/40 Breakfast cereals targeted at children contain 'steadily high' sugar levels since 1992 despite producer claims A major pressure group has issued a fresh warning about perilously high amounts of sugar in breakfast cereals, specifically those designed for children, and has said that levels have barely been cut at all in the last two and a half decades Getty 18/40 Potholes are making us fat, NHS watchdog warns New guidance by the National Institute for Health and Care Excellence (NICE), the body which determines what treatment the NHS should fund, said lax road repairs and car-dominated streets were contributing to the obesity epidemic by preventing members of the public from keeping active PA 19/40 New menopause drugs offer women relief from 'debilitating' hot flushes A new class of treatments for women going through the menopause is able to reduce numbers of debilitating hot flushes by as much as three quarters in a matter of days, a trial has found. The locus resides within an “enhancer” element; enhancers are short DNA sequences that control the extent to which a gene is turned on or off.

Interestingly, we also found evidence that an increased risk of type 2 diabetes also causes an increased risk of ED. If there is a problem with one or more of these mechanisms, the erection may fail. The researchers found that DNA sequence variations at a position in the genome (i. )Arackal BS, Benegal V. Jump to Section 1. Scientists say they have identified an area of the genome which increases the risk of impotence, raising hopes of new therapies to treat the condition. There are certain things that can cause erectile dysfunction which may run in families, but the condition itself isn’t genetic.


Having learned a great deal more about erectile dysfunction including its risk factors and causes, you should be equipped to assess your own erectile function. They found that men with ED were more likely to have a high risk factor score for type 2 diabetes, compared with men without ED. It has been estimated that nearly one in every ten men would have such complaints, being four times more common in men aged in their 60s than those in their 40s. Europe PMC requires Javascript to function effectively.